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Faculty of Health Sciences

Gupta Lab

Lifetime Publications

Cytochrome-C localizes in secretory granules in pancreas and anterior pituitary

Expandable List

  1. Singh, U.N. and Gupta, R.S. (1971). Polyribosomes and unstable messenger RNA. II. Some further implications of the tape theory of protein synthesis. J. Theoret. Biol. 30, 603-619.
  2. Gupta, R.S. and Singh, U.N. (1972). Biogenesis of ribosomes: Free ribosomal protein pools in Escherichia coli. J. Mol. Biol. 69: 279-301.
  3. Gupta, R.S. and Singh, U.N. (1972). Initiation of transcription and the sequential synthesis of 16-S and 23-S ribosomal RNA in Escherichia coli. Biochim. Biophys. Acta 277, 567-576.
  4. Gupta, R.S. (1975). Killing and lysis of Escherichia coli in the presence of chloramphenicol: relation to cellular magnesium. Antimicrob. Agents and Chemotherapy 7: 648-653.
  5. Gupta, R.S. and Schlessinger, D.(1975). Differential modes of chemical decay for early and late lambda messenger RNA. J. Mol. Biol. 92: 3ll-318.
  6. Gupta, R.S. and Schlessinger, D. (1976). Coupling of rates of transcription, translation, and messenger ribonucleic acid degradation in streptomycin-dependent mutants of Escherichia coli. J. Bacteriol. 125: 84-93.
  7. Kasai, T., Gupta, R.S. and Schlessinger, D. (1977). Exoribonucleases in wild type Escherichia coli and RNase II-deficient mutants. J. Biol. Chem. 252: 8950-8956.
  8. Gupta, R.S., Kasai, T. and Schlessinger, D. (1977). Purification and some novel properties of Escherichia coli RNase II. J. Biol. Chem. 252: 8945-8949.
  9. Schlessinger, D., Jacob, K., Gupta, R., Imamoti, F. and Kano, Y. (1977). Decaying of individual E. coli trp mRNA molecules is sequentially ordered. J. Mol. Biol. 110: 421-439.
  10. Gupta, R.S. and Siminovitch, L. (1976). The isolation and preliminary characterization of somatic cell mutants resistant to the protein synthesis inhibitor-emetine. Cell 9: 213-219.
  11. Gupta, R.S. and Siminovitch. L. (1977). The molecular basis of emetine resistance in Chinese hamster ovary cells: Alteration in the 40S ribosomal subunit. Cell 10: 61-66.
  12. Gupta, R.S., Flintoff, W.F. and Siminovitch, L. (1977). Purification and properties of dihydrofolate reductase from methotrexate-sensitive and resistant Chinese hamster ovary cells. Can. J. Biochem. 55: 445-452.
  13. Gupta, R.S. and Siminovitch, L. (1977). Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: Genetic and structural evidence for common site of action of emetine, cryptopleurine, tylocrebrine and tubulosine. Biochemistry 16: 3209-3214.
  14. Gupta, R.S. and Siminovitch, L. (1978). Mutants of CHO cells resistant to the protein synthesis inhibitor emetine: Genetic and biochemical characterization of second-step mutants. Somat. Cell Genet. 4: 77-94.
  15. Gupta, R.S. and Siminovitch, L. (1978). An in vitro analysis of the dominance of emetine sensitivity in Chinese hamster ovary cell hybrids. J. Biol. Chem. 253: 3978-3982.
  16. Gupta, R.S. and Siminovitch, L. (1978). Genetic and biochemical characterization of mutants of CHO cells resistant to the protein synthesis inhibitor trichodermin. Somat. Cell Genet. 4: 355-374.
  17. Gupta, R.S. and Siminovitch, L. (1978). The isolation and characterization of mutants of human diploid fibroblasts resistant to diphtheria toxin. Proc. Natl. Acad. Sci. USA 75: 3337-3340.
  18. Gupta, R.S. and Siminovitch, L. (1978). Diphtheria-toxin-resistant mutants of CHO cells affected in protein synthesis: a novel phenotype. Somat. Cell Genet. 4: 553-571.
  19. Gupta, R.S., Chan, D.H.Y. and Siminovitch, L. (1978). Evidence for functional hemizygosity at the Emtr locus in CHO cells through segregation analysis. Cell 15: 1007-1013.
  20. Gupta, R.S., Chan, D.H.Y. and Siminovitch, L.(1978). Evidence for variation in the number of functional gene copies at the AmaR locus in Chinese hamster cell lines. J. Cell. Physiol. 97: 461-468.
  21. Gupta, R.S., and Siminovitch, K.L. (1978). Genetic and biochemical studies with the adenosine analogs toyocamycin and tubercidin: mutation at the adenosine kinase locus in Chinese hamster cells. Somat. Cell Genet. 4: 715-736.
  22. Gupta, R.S., Krepinsky, G.H. and Siminovitch, L. (1980). Structural determinants responsible for the biological activity of (-)-emetine, (-)-cryptopleurine, and (-)-tylocrebrine: structure-activity relationship among related compounds. Mol. Pharmacol. 18: 136-143.
  23. Gupta, R.S. (1980). Random segregation of multiple genetic markers from CHO-CHO hybrids: evidence for random distribution of functional hemizygosity in the genome. Som. Cell Genet. 6: 115-125.
  24. Gupta, R.S.(1980). Senescence of cultured human diploid fibroblasts. Are mutations responsible? J. Cell. Physiol. 103: 209-216.
  25. Gupta, R.S. and Siminovitch, L. (1980). DRB resistance in Chinese hamster and human cells: genetic and biochemical characteristics of the selection system. Som. Cell Genet. 6: 151-169.
  26. Gupta, R.S. and Siminovitch, L. (1980). Pactamycin resistance in CHO cells: morphological changes induced by the drug in the wild-type and mutant cells. J. Cell. Physiol. 102: 305-316.
  27. Gupta, R.S. and Siminovitch, L. (1980). Genetic markers for quantitative mutagenesis studies in Chinese hamster ovary cells: Characteristics of some recently developed selective systems. Mut. Res. 69: 113-126.
  28. Gupta, R.S. and Siminovitch, L. (1980). Diphtheria toxin resistance in Chinese hamster cells: Genetic and biochemical characteristics of the mutants affected in protein synthesis. Som. Cell Genet. 6: 361-379.
  29. Srinivasan, P.R., Gupta, R.S. and Siminovitch, L. (1980). Studies on temperature-sensitive mutants of Chinese hamster ovary cells affected in DNA synthesis. Som. Cell Genet. 6: 567-582.
  30. Gupta, R.S. (1980). Repeated mutagenesis and the selection of recessive and dominant mutations in cultured mammalian cells. Mut. Res. 74: 503-508.
  31. Gupta, R.S. (1980). A novel synergistic effect of alanosine and guanine on adenine nucleotide synthesis in mammalian cells. Alanosine as a useful probe for investigating purine nucleotide metabolism. J. Cell. Physiol. 104: 241-248.
  32. Gupta, R.S. (1980). Diphtheria toxin resistance in human lymphoblast lines. Biochem. Biophys. Res. Commun. 94: 1303-1310.
  33. Gupta, R.S. and Goldstein, S. (1980). Diphtheria toxin resistance in human fibroblast cell strains from normal and cancer-prone individuals. Mut. Res. 73: 331-338.
  34. Gupta, R.S. (1981). Resistance to the microtubule inhibitor podophyllotoxin: selection and partial characterization of mutants in CHO cells. Som. Cell Genet. 7: 59-71.
  35. Gupta, R.S. and Hodgson, M. (1981). Genetic markers in mouse teratocarcinoma cells. Selection and partial characterization of mutants resistant to toyocamycin, DRB and podophyllotoxin. Exp. Cell Res. 132: 496-500.
  36. Gupta, R.S. (1981). Podophyllotoxin resistance: a codominant selection system for quantitative mutagenesis studies in mammalian cells. Mut. Res. 83: 261-270.
  37. Gupta, R.S. (1981). Mutants of HeLa cells resistant to ouabain and cassaine: genetic evidence for the common site of action of cardiac glycosides and erythrophleum alkaloids. Biochem. Pharmacol. 30: 3039-3444.
  38. Gupta, R.S., Ho, T.K.W., Moffat, M.R.K. and Gupta, R. (1982). Podophyllotoxin-resistant mutants of Chinese hamster ovary cells. Alteration in a microtubule-associated protein. J. Biol. Chem. 257: 1071-1078.
  39. Gupta, R.S. and Singh, B. (1982). Mutagenic response of five independent genetic loci in CHO cells to a variety of mutagens: Development and characteristics of a mutagen screen system based on selection for multiple drug resistance markers. Mut. Res. 94: 449-466.
  40. Gupta, R.S. and Goldstein, S. (1982). Human fibroblast strains showing increased sensitivity or resistance to ethidium bromide. Mut. Res. 105: 183-188.
  41. Gupta, R.S. and Moffat, M.R.K. (1982). Synergistic effect of adenine and related purine derivatives on the toxicity of pyrazofurin and 6-azauridine in mammalian cells. J. Cell. Physiol. 111: 291-294.
  42. Gupta, R.S. (1982). Species specific differences in the toxicity of mithramycin, chromomycin A3 and olivomycin towards cultured mammalian cells. J. Cell. Physiol. 113: 11-16.
  43. Singh, B. and Gupta, R.S. (1982). Mutagenic responses to ultraviolet light and X-rays at five independent genetic loci in Chinese hamster ovary cells. Env. Mut. 4: 543-551.
  44. Singh, B. and Gupta, R.S. (1983). Mutagenic responses of thirteen anticancer drugs on mutation induction at multiple genetic loci and on sister chromatid exchanges in Chinese hamster ovary cells. Cancer Res. 43: 577-584.
  45. Gupta, R.S. (1983). Taxol resistant mutants of Chinese hamster ovary cells: genetic, biochemical, and cross-resistance studies. J. Cell. Physiol. 114: 137-144.
  46. Gupta, R.S. (1983). Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues. Cancer Res. 43: 505-512.
  47. Gupta, R.S. (1983). Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213. Cancer Res. 43: 1568-1574.
  48. Gupta, R.S. and Singh, B. (1983). Quantitative mutagenesis at the adenosine kinase locus in Chinese hamster ovary cells. Development and characteristics of the selection system. Mut. Res. 113: 441-454.
  49. Mehta, K.D. and Gupta, R.S. (1983). Formycin B-resistant mutants of Chinese hamster ovary cells: novel genetic and biochemical phenotype affecting adenosine kinase. Mol. Cell. Biol. 3: 1468-1477.
  50. Singh, B. and Gupta, R.S. (1983). Comparison of the mutagenic responses of 12 anticancer drugs at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci in Chinese hamster ovary cells. Env. Mut. 5: No. 6, 871-880.
  51. Gupta, R.S. and Gupta, R. (1984). Mutants of Chinese hamster ovary cells affected in two different microtubule associated proteins: Genetic and biochemical studies. J. Biol. Chem. 259: 1882-1890.
  52. Gupta, R.S. and Singh, B. (1984). 4′-Demethylepipodophyllotoxin-beta-D-glucoside: a new podophyllotoxin derivative with VM-26-like and VP-16-213-like activities. J. Nat. Cancer Inst. 73: 241-248.
  53. Gupta, R.S. and Mehta, K.D. (1984). Genetic and biochemical studies on mutants of CHO cells resistant to 7-deazapurine nucleosides: differences in the mechanisms of action of toyocamycin and tubercidin. Biochem. Biophys. Res. Commun. 120: 88-98.
  54. Gupta, R.S. (1984). Griseofulvin resistance mutation of Chinese hamster ovary cells that affects the apparent molecular weight of a congruent to 200,000-dalton protein. Mol. Cell. Biol. 4: 1761-1768.
  55. Gupta, R.S. (1985). Cross-resistance of vinblastine- and taxol-resistant mutants of Chinese hamster ovary cells to other anticancer drugs. Cancer Treat. Report 69: 525-521.
  56. Gupta, R.S. (1985). Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells. J. Nat. Cancer Inst. 74: 159-164.
  57. Singh, B. and Gupta, R.S. (1985). Species specific differences in the toxicity of mithramycin, chromomycin A3, and olivomycin towards cultured mammalian cells. Cancer Res. 45: 2813-2820.
  58. Gupta, R.S. and Chopra, A. (1985). Cross resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides: The unusual behavior of cardenolide SC4453. J. Biol. Chem. 260: 6843-6850.
  59. Gupta, R.S., Venner, T. and Chopra, A. (1985). Genetic and biochemical studies with mutants of mammalian cells affected in microtubule-related proteins other than tubulin: mitochondrial localization of a microtubule-related protein. Can. J. Biochem. Cell Biol. 63: 489-502.
  60. Mehta, K.D. and Gupta, R.S. (1985). Involvement of adenosine kinase in the phosphorylation of formycin B in CHO cells. Biochem. Biophys. Res. Commun. 130: 910-917.
  61. Gupta, R.S. and Singh, B. (1985). Autoradiographic detection of diphtheria toxin resistant mutants in human diploid fibroblasts. Env. Mut. 7: 611-624.
  62. Gupta, R.S., Singh, B. and Stetsko, D.K. (1985). Inhibition of metabolic cooperation by phorbol esters in a cell culture system based on adenosine kinase deficient mutants of V79 cells. Carcinogenesis 6: 1359-1366.
  63. Mehta, K.D. and Gupta, R.S. (1985). Chinese hamster ovary cell mutants specifically affected in the phosphorylation of C-purine nucleosides. Can. J. Biochem. Cell. Biol. 63: 1044-1048.
  64. Mehta, K.D. and Gupta, R.S. (1986). Novel mutants of CHO cells resistant to adenosine analogs and containing biochemically altered form of adenosine kinase in cell extracts. Som. Cell. & Mol. Genet. 12: 21-31.
  65. Chopra, A. and Gupta, R. S. (1986). Biochemical and cross-resistance studies with HeLa cell mutants resistant to cardiac glycoside SC4453. Regulation of the resistant form of Na+/K+-ATPase in the mutant cells. J. Biol. Chem. 261: 2034-2040.
  66. Gupta, R.S. and Venner, T.J. (1986). Mitochondrial localization of a microtubule-related protein. Ann. New York Acad. Sci. 466: 854-857.
  67. Gupta, R.S and Mehta, K.D. (1986). Immunological studies with different classes of mutants affected at the adenosine kinase locus in CHO cells. Som. Cell. Mol. Genet. 12: 265.
  68. Gupta, R.S., Chopra, A. and Stetsko, D.K. (1986). Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). J. Cell. Physiol. 127: 297-306.
  69. Glisson, B., Gupta, R.S., Smallwood-Kentro, S. and Ross, W. (1986). Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity. Cancer Res. 46: 1934-1938.
  70. Glisson, B., Gupta, R.S., Hodges, P. and Ross, W. (1986). Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target. Cancer Res. 46: 1939-1942.
  71. Gupta, R.S. (1986). Cross-resistance of nocodazole-resistant mutants of CHO cells toward other microtubule inhibitors: similar mode of action of benzimidazole carbamate derivatives and NSC 181928 and TN-16. Mol. Pharmacol. 30: 142-148.
  72. Chopra, A. and Gupta, R.S. (1986). Ouabain-resistant mutants of Chinese hamster ovary cells are not directly affected in Na+, K+-ATPase. Som. Cell. & Mol. Genet. 12: 367-373.
  73. Gupta, R.S. and Dudani, A.K. (1987). Species-specific differences in the toxicity of rhodamine 123 toward cultured mammalian cells. J. Cell. Physiol. 130: 321-327.
  74. Dudani, A.K. and Gupta, R.S. (1987). Effect of chlorpromazine and trifluoperazine on cytoskeletal components and mitochondria in cultured mammalian cells. Tissue and Cel 19: 183-196.
  75. Gupta, R.S., Bromke, A., Bryant, D.W., Gupta, R., McCalla, D.R. and Singh, B. (1987). Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems. Mutagenesis 2: 179-186.
  76. Gupta, R.S. (1987) Identification of 2-benzimidazolyl urea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of CHO cells. Biochem. Biophys. Res. Commun. 145: 225-232.
  77. Gupta, R.S. and Chopra, A. (1987) Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor. Biochem. Pharmacol. 36: 3829-3833.
  78. Li, A.P., Carver, J.H., Choy, W.N., Hsie, A.W., Gupta, R.S., Loveday, K.S., O’Neill, J.P., Riddle, J.C., Stankowski, L.F. Jr. and Yang, L.L. (1987) A guide for the performance of the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase gene mutation assay. Mutation Res. 189: 135-141.
  79. Glisson, B.S. Sullivan, D.M., Gupta, R.S. and Ross, W.E. (1987). Mediation of multi-drug resistance in a Chinese hamster ovary cell line by a mutant type II topoisomerase. NCI Monograph. No. 4: 89-93.
  80. Gupta, R.S., Chenchaiah, P.C. and Gupta, R. (1987). Synthesis and structure-activity relationships among glycosidic derivatives of 4′-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities. Anti-Cancer Drug Design 2: 1-12.
  81. Gupta, R. S. and Chenchaiah, P.C. (1987). Synthesis and biological activities of the C-4 esters of 4′-demethylepipodophyllotoxin. Anti-Cancer Drug Design 2: 13-23.
  82. Gupta, R.S. and Dudani, A.K. (1987). Mitochondrial binding of a protein affected in mutants resistant to the microtubule inhibitor podophyllotoxin. Eur. J. Cell Biol. 44: 278-285.
  83. Gupta, R.S. and Austin, R.A. (1987). Mitochondrial matrix localization of a protein affected in mutants resistant to the microtubule inhibitor podophyllotoxin. Eur. J. Cell Biol. 45:170-176.
  84. Dudani, A.K. and Gupta, R. S.(1987). Absence of gene amplification in human cell mutants resistant to cardiac glycosides. Mol. Cell. Biochem. 78: 73-79.
  85. Li, A.P., Gupta, R.S., Heflich, R.H. and Wassom, J.S. (1988) A review and analysis of the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase assay to determine the mutagenicity of chemical agents. A report of phase III of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research 196: 17-36.
  86. Gupta, R.S., Murray, W. and Gupta, R. (1988). Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line. Br. J. Cancer 58: 441-447.
  87. Dudani, A.K., Gupta, R.S. and Gupta, R. (1988). Species-specific differences in the toxicity of puromycin towards cultured human and Chinese hamster cells. FEBS Letts. 234: 141-144.
  88. Gupta, R.S. (1988). Intrinsic multidrug resistant phenotype of Chinese hamster (rodent) cells in comparison to human cells. Biochem. Biophys. Res. Commun. 153: 598-605.
  89. Gupta, R.S., Gupta, R., Eng, B., Lock, R.B., Ross, W.E., Hertzberg,. R., Caranfa, M.J. and Johnson, R.K. (1988). Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I. Cancer Res. 48: 6404-6410.
  90. Gupta, R.S. and Dudani, A.K. (1989). Mechanism of action of antimitotic drugs: a new hypothesis based on the role of cellular calcium. Medical Hypothesis 28:57-69.
  91. Jindal, S., Dudani, A.K., Singh, B., Harley, C.B. and Gupta, R.S (1989). Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kDa mycobacterial antigen. Mol. Cell Biol. 9: 2279-2283.
  92. Gupta, R.S., Chopra, A. and Trott, A.B. (1989). Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants. Biochem. Pharmacol. 38: 2159-2168.
  93. Picketts, D.J., Mayanil, C.S.K. and Gupta, R.S. (1989). Molecular cloning of a Chinese hamster mitochondrial protein related to the “chaperonin” family of bacterial and plant proteins. J. Biol. Chem. 264: 12001-12008.
  94. Dudani, A.K. and Gupta, R.S. (1989). Immunological characterization of a human homolog of the 65-kilodalton mycobacterial antigen. Infect. & Immun. 57: 2786-2793.
  95. Gupta, R.S., Picketts, D. and Ahmad, S. (1989). A novel ubiquitous protein ‘chaperonin’ supports the endosymbiotic origin of mitochondrion and plant chloroplast. Biochem. Biophys. Res. Commun. 163: 780-787.
  96. Mackinnon, W.B., Dyne, M., Holmes, K.T., Gupta R.S. and Mountford, C.E. (1989). Further evidence that the narrow 1H magnetic resonance signals from malignant cells do not arise from intracellular lipid droplets. NMR in Biomed. 2: 161-164.
  97. Boscoboinik, D., Gupta, R.S. and Epand, R.M. (1990). Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells. Br. J. Cancer 61: 568-572.
  98. Gupta, R.S. (1990). Sequence and structural homology between a mouse T-complex protein TCP-1 and the ‘chaperonin’ family of bacterial (GroEL, 60-65 kDa heat shock antigen) and eukaryotic proteins. Biochem. Int. 20: 833-841.
  99. Chopra, A., Dudani, A.K. and Gupta, R.S. (1990). Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides. Biochem. Cell Biol. 68: 852-857.
  100. Singh, B., Patel, H.V., Ridley, R.G., Freeman, K.B. and Gupta, R.S. (1990). Mitochondrial import of the human chaperonin (HSP60) protein. Biochem. Biophys. Res. Commun. 169: 391-396.
  101. Ahmad, S., Ahuja, R., Venner, T. and Gupta, R.S. (1990). Identification of a protein altered in mutants resistant to microtubule inhibitors as a member of the major heat shock protein (hsp70) family. Mol. Cell Biol. 10: 5160-5165.
  102. Boscoboinik, D., Debanne, M.T., Stafford, A.R., Jung, C.Y., Gupta, R.S. and Epand, R.M. (1990). Dimerization of the P-glycoprotein in membranes. Biochim. Biophys. Acta 1027: 225-228.
  103. Gupta, R.S. (1990). Microtubule, mitochondria and molecular chaperones: a new model for in vivo assembly of microtubules. Biochem. Cell Biol. 68: 1352-1363.
  104. Dudani, A.K., Austin, R., Venner, T.J. and Gupta, R.S. (1990). Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria. Cytobios. 63: 95-108.
  105. Venner, T.J., Singh, B. and Gupta, R.S. (1990). Nucleotide sequence and novel structural aspects of human and Chinese hamster hsp60 (chaperonin) gene family. DNA and Cell Biol. 9: 545-552.
  106. Ahmad, S. and Gupta, R.S. (1990). Cloning of a Chinese hamster ovary cell protein homologous to the mouse t-complex protein TCP-1: Structural similarity to the ubiquitous “chaperonin” family of heat shock proteins. Biochim. Biophys. Acta 1087: 253-255.
  107. Gupta, R.S. (1990) Mitochondria, molecular chaperone proteins and the in vivo assembly of microtubules. Trends in Biochem. Sc. 15: 415-418.
  108. Venner, T.J. and Gupta, R.S. (1990) Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA. Nucl. Acids Res. 18: 5309.
  109. Venner, T.J. and Gupta, R.S. (1990) Nucleotide sequence of mouse hsp60 (chaperonin, GroEL homolog) cDNA. Biochim. Biophys. Acta 1087: 336-338.
  110. Epand, R.F., Epand, R.M., Gupta, R.S. and Cragoe, E.J. Jr. (1991) Reversal of intrinsic multidrug resistance in Chinese hamster ovary cells by amiloride analogs. Br. J. Cancer 63: 247-251.
  111. Haregewoin, A., Singh, B., Gupta, R.S. and Finberg, R.W. (1991) A mycobacterial heat-shock protein-responsive gamma delta T cell clone also responds to the homologous human heat-shock protein: a possible link between infection and autoimmunity. J. Infect. Diseases 163: 156-160.
  112. Sicheri, F., Derry, W.B., Gupta, R.S. and Yang, D.S.C. (1991) Crystal structure of 4′-demethyl epipodophyllotoxin-9-(3′-thymidine). Acta Crystallographica C47, 2479-2482.
  113. Ahmad, S., Singh,B. and Gupta, R.S. (1991) Nucleotide sequences of three different isoforms of beta-tubulin cDNA from Chinese hamster ovary cells. Biochim. Biophys. Acta. 1090: 252-259.
  114. Pamidi, C.C., Derry, B. and Gupta, R.S. (1992). Synthesis and biological activity of 4′-demethylepipodophyllotoxin-β -D-galactoside derivatives showing VP16 (etoposide)-like activity. Anticancer Drug Design 6: 481-493.
  115. Pope, R.M., Lovis, R.M. and Gupta, R.S. (1992) Activation of synovial fluid T lymphocytes by 60-kd heat-shock proteins in patients with inflammatory synovitis. Arthritis and Rheumatism 35: 43-48.
  116. Brudzynski, K., Martinez, V. and Gupta, R.S. (1992) Immunocytochemical localization of heat-shock protein 60-related protein in beta-cell secretory granules and its altered distribution in non-obese diabetic mice. Diabetologia 35: 316-324.
  117. Viitanen, P.V., Lorimer, G.H., Seetharam, R., Gupta, R.S., Oppenheim, J., Thomas, J.O. and Cowan, N.J. (1992) Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring. J. Biol. Chem. 267: 695-698.
  118. Singh, B. and Gupta, R.S. (1992) Expression of human 60-kD heat shock protein (HSP60 or P1) in Escherichia coli and the development and characterization of corresponding monoclonal antibodies. DNA and Cell Biol. 11: 489-496.
  119. Rusanganwa, E., Singh, B. and Gupta, R.S. (1992) Cloning of HSP60 (GroEL) operon from Clostridium perfringens using a polymerase chain reaction based approach. Biochim. Biophys. Acta 1130: 90-94.
  120. Galley, K.A., Singh, B. and Gupta, R.S. (1992) Cloning of HSP70 (DnaK) from Clostridium perfringens using a general PCR based approach. Biochim. Biophys. Acta 1130: 203-208.
  121. Gupta, R.S. and Singh, B. (1992) Cloning of the HSP70 gene from Halobacterium marismortui: relatedness of archaebacterial HSP70 to its eubacterial homologs and a model for the evolution of the HSP70 gene. J. Bacteriol. 174: 4594-4605.
  122. Deffie, A.M., McPherson, J.P., Gupta, R.S., Hedley, D.W. and Goldenberg, G.H. (1992) Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II. Biochem. Cell Biol. 70: 354-364.
  123. Bowen-Jones, D., Fantes, J. and Gupta, R.S. (1992) Diabetes and heat shock proteins. Nature 355: 119-120.
  124. Sicheri, F.V., Derry, W.B., Gupta, R.S. and Yang, D.S-.C. (1992) Structure of 4′-demethylepipodophyllotoxin. Acta Cryst. C48: 747-749.
  125. Li, S.G., Quayle, A.J., Shen, Y., Kjeldsen-Kragh, J., Oftung, F., Gupta, R.S., Natvig, J.B. and Forre, O.T. (1992) Mycobacteria and human heat shock protein-specific cytotoxic T lymphocytes in rheumatoid synovial inflammation. Arth. & Rheum. 35: 270-281.
  126. Brudzynski, K., Martinez, V. and Gupta, R.S. (1992) Secretory granule autoantigen in insulin-dependent diabetes mellitus is related to 62 kDa heat-shock protein (hsp60). J. Autoimmunity 5: 453-463.
  127. Sharif, M., Worral, J.G., Singh, B., Gupta, R.S., Lydyard, P.M., Lambert, C., McCulloch, J. and Rook, G.A. (1992) The development of monoclonal antibodies to the human mitochondrial 60-kd heat-shock protein, and their use in studying the expression of the protein in rheumatoid arthritis. Arth. & Rheum. 35: 1427-1433.
  128. Soltys, B.J. and Gupta, R.S (1992) Interrelationships of endoplasmic reticulum, mitochondria, intermediate filaments and microtubules — a quadruple fluorescence labeling study. Biochem. Cell Biol. 70: 1174-1186.
  129. Sicheri, F.V., Derry, W.B., Gupta, R.S. and Yang, D.S.-C. (1992) Structure of 5-hydroxyethoxy-6-[1-(4-methoxyphenyl)ethyl]1,3-benzodioxole. Acta Cryst. C48: 1687-1689.
  130. Kaur, I., Voss, S.D., Gupta, R.S., Schell, K., Fisch, P. and Sondel, P.M. (1993) Human peripheral gamma delta T cells recognize hsp60 molecules on Daudi Burkitt’s lymphoma cells. J. Immunol. 150: 2046-2055.
  131. Rusanganwa, E. and Gupta, R.S. (1993) Cloning and characterization of multiple groEL chaperonin-encoding genes in Rhizobium meliloti. Gene 126: 67-75.
  132. Derry, W.B., Chenchaiah, P.C. and Gupta, R.S. (1993) Synthesis and biological activity of novel thymidine derivatives of podophyllotoxin and 4′-demethylepipodophyllotoxin. Anticancer Drug Des. 8: 203-224.
  133. Gupta, R.S. and Golding, G.B. (1993) Evolution of HSP70 gene and its implications regarding relationships between archaebacteria, eubacteria, and eukaryotes. J. Mol. Evol. 37: 573-582.
  134. Bruschi, S.A., West, K.A., Crabb, J.W., Gupta, R.S. and Stevens, J.L. (1993) Mitochondrial HSP60 (P1 protein) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity. J. Biol. Chem. 268: 23157-23161.
  135. Lopez-Guerrero, J.A., Lopez-Bote, J.P., Ortiz, M.A., Gupta, R.S., Paez, E. and Bernabeu, C. (1993) Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein. Infect. Immun. 61: 4225-4231.
  136. Cha, S., Leung, P., Taubeneck, M.W., Keen, C.L., Gershwin, M.E., Gupta, R.S. and Fletcher, M.P. (1993) Effects of zinc deprivation on heat shock protein (HSP)-65 and -70 gene expression in pregnant rats. Nutrition Res. 13: 1077-1086.
  137. Agsteribbe, E., Huckriede, A., Veenhuis, M., Ruiters, M.H.J., Niezen-Koning, K.E., Skjeldal, O.H., Skullerud, K., Gupta, R.S., Hallberg, H., van Diggelen, O.P. and Scholte, H.R. (1993) A fatal, systemic mitochondrial disease with decreased mitochondrial enzyme activities, abnormal ultrastructure of the mitochondria and deficiency of heat shock protein 60. Biochem. Biophys. Res. Commun. 193: 146-154.
  138. Xu, Q., Luef, G., Weimann, S., Gupta, R.S., Wolf, H. and Wick, G. (1993) Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein-reactive antisera. Arterioscler. Thromb. 13: 1763-1769.
  139. Baca-Estrada. M.E., Gupta, R.S., Stead, R.H. and Croitoru, K. (1994) Intestinal expression and cellular immune responses to human heat-shock protein 60 in Crohn’s disease. Digest. Disease. Sciences 39: 498-506.
  140. Soltys, B. and Gupta, R.S. (1994) Changes in mitochondrial shape and distribution induced by ethacrynic acid and the transient formation of a mitochondrial reticulum. J. Cell. Physiol. 159: 281-294.
  141. Jones, M., Gupta, R.S. and Englesberg, E (1994) Enhancement in amount of P1 (hsp60) in mutants of Chinese hamster ovary (CHO-K1) cells exhibiting increases in the A system of amino acid transport. Proc. Natl. Acad. Sci. USA 91: 858-862.
  142. Gupta, R.S., Aitken, K., Falah, M. and Singh, B. (1994) Cloning of Giardia lamblia heat shock protein HSP70 homologs: implications regarding origin of eukaryotic cells and of endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 91: 2895-2899
  143. Lake, J.A. and Rivera, M.C. (1994) Was the nucleus the first endosymbiont? Proc. Natl. Acad. Sci USA 91: 2880-2881. (Commentary on Ref. 142).
  144. Gupta, R.S. (1994) Identification of a GroES (CPN10)-related sequence motif in the GroEL (CPN60) chaperonins. Biochem. Mol. Biol. International 33: 591-595.
  145. Epand, R.M., Epand, R.F., Harkey, D.L., Gupta, R.S. and Cragoe, E.J. Jr. (1994) Insensitivity of a multidrug resistant cell line to cyclosporin. The Cancer Journal 7: 85-90.
  146. Sharma, S.A., Miller, G.G., Perez-Perez, G.I., Gupta, R.S. and Blaser, M.J. (1994) Humoral and cellular immune recognition of Helicobacter pylori proteins are not concordant. Clin. Exp. Immunol. 97: 126-132.
  147. Soltys, B.J. and Gupta, R.S. (1994) Presence and cellular distribution of a 60-kDa protein related to mitochondrial hsp60 in Giardia lamblia. 80: 580-590.
  148. Prabhakar, S., Kurien, E., Gupta, R.S., Zielinski, S. and Friedman, M.S. (1994) Heat shock protein immunoreactivity in CSF: correlation with oligoclonal banding and demyelinating disease. Neurology 44: 1644-1648.
  149. Gupta, R.S. and Singh, B. (1994) Phylogenetic analysis of 70 kD heat shock protein sequences suggests a chimeric origin for the eukaryotic cell nucleus. Current Biol. 4: 1104-1114.
  150. Irwin, D.M. (1994) Molecular evolution. Who are the parents of eukaryotes? Current Biol 4: 1115-1117. (Commentary on Ref. 149)
  151. Gupta, R.S., Golding, G.B. and Singh, B. (1994) HSP70 phylogeny and the relationship between archaebacteria, eubacteria and eukaryotes. J. Mol. Evol. 39: 539-540.
  152. Falah, M. and Gupta, R.S. (1994) Cloning of the hsp70 (dnaK) genes from Rhizobium meliloti and Pseudomonas cepacia: phylogenetic analyses of mitochondrial origin based on a highly conserved protein sequence. J. Bacteriol. 176: 7748-7753.
  153. Soltys, B.J. and Gupta, R.S. (1994) Immunoelectron microscopy of Giardia lamblia cytoskeleton using antibody to acetylated alpha-tubulin. J. Eukaryotic Microbiol. 41: 625-632.
  154. Xu, Q., Schett, G., Seitz, C.S., Hu, Y., Gupta, R.S. and Wick, G. (1994) Surface staining and cytotoxic activity of heat shock protein 60 antibody on stressed aortic endothelial cells. Circulation Res. 75: 1078-1085.
  155. Golding, G.B. and Gupta, R.S. (1995) Protein-based phylogenies support a chimeric origin for the eukaryotic genome. Mol. Biol. Evol. 12: 1-6.
  156. Gupta, R.S. (1995) Microreview: Evolution of the chaperonin families (HSP60, HSP10 and Tcp-1) of proteins and the origin of eukaryotic cells. Mol. Microbiol. 15: 1-11.
  157. Gupta, R.S. (1995) Phylogenetic analysis of the 90 kD heat shock family of protein sequences and an examination of the relationship among animals, plants, and fungi species. Mol. Biol. Evol. 12: 1063-1073.
  158. Handley, H.H., Ngyuen, M.D., Yu, D.T., Gupta, R.S. and Vaughan, J.H. (1995) Purification of recombinant human Hsp60: use of a GroEL-free preparation to assess autoimmunity in rheumatoid arthritis. J. Autoimmun. 8: 659-673.
  159. Soltys, B.J. and Gupta, R.S. (1996) Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Exp. Cell Res. 222: 16-27.
  160. Gupta, R.S., Gupta, R. and Goldstein, S. (1996) Screening for genetic predisposition to mutagens in cancer patients. Experimental Gerontology 31: 267-280.
  161. Handley, H.H., Yu, J., Yu, D.T.Y., Singh, B., Gupta, R.S. and Vaughan, J.H. (1996) Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL. Clinical Exp. Immunology, 103: 429-435.
  162. Hao, W. and Gupta, R.S. (1996) Pentavalent ion dependency of mammalian adenosine kinase. Biochem. Mol. Biol. International 38: 889-899.
  163. Gupta, R.S. and Soltys, B.J. (1996) Prokaryotic homolog of tubulin? Consideration of FtsZ and glyceraldehyde 3-phosphate dehydrogenase as probable candidates. Biochem. Mol. Biol. International 38, 1211-1221.
  164. Gupta, R.S. and Golding, G.B. (1996) The origin of the eukaryotic cell. Trends Biochem. Sci. 21: 166-171.
  165. Soltys, B.J., Falah, M.S. and Gupta, R.S. (1996) Identification of endoplasmic reticulum in the primitive eukaryote Giardia lamblia using cryoelectron microscopy and antibody to Bip. J. Cell Science 109: 1909-1917.
  166. Gupta, R.S. (1996) Adenosine-AMP exchange activity is an integral part of the mammalian adenosine kinase. Biochem. Mol. Biol. Internat. 39: 493-502.
  167. Xu, Q.B., Kleindienst, R., Schett, G., Jindal, S., Gupta, R.S., Dietrich, H., Wick, G. (1996) Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits. Atherosclerosis, 123, 145-155.
  168. Singh, B., Hao, W., Wu, Z-C., Eigle, B. and Gupta, R.S. (1996) Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene. E.J. Biochem. 241: 564-571.
  169. Gupta, R.S. and Golding, G.B. (1996) Reply to a chimeric origin for eukaryotes re-examined. Trend Biochem. Sci.21, 372.
  170. Soltys, B.J. and Gupta, R.S. (1996) Cell surface localization of the 60 kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Cell Biololgy International 21: 315-320.
  171. Falah, M. and Gupta, R.S. (1997) Phylogenetic analysis of mycoplasmas based on Hsp70 sequences: cloning of the dnaK (hsp70) gene region of Mycoplasma capricolum. Int. J. System. Bacteriol. 47:38-45.
  172. Singh, B., Soltys, B., Wu, Z-C., Patel, H.V., Freeman, K.B. and Gupta, R.S. (1997) Cloning and some novel characteristics of mitochondrial HSP70 from Chinese hamster cells. Exp. Cell Res. 234: 205-216.
  173. Gupta, R.S. (1997) Protein phylogenies and signature sequences: evolutionary relationships within prokaryotes and between prokaryotes and eukaryotes. Antonie van Leeuwenhoek 72:49-61.
  174. Gupta, R. S., Bustard, K, Falah, M. and Singh, D. (1997) Sequencing of heat shock protein 70 (DnaK) homologs from Deinococcus proteolyticus and Thermomicrobium roseum and their integration in a protein-based phylogeny of prokaryotes. J. Bacteriol. 179, 345-357.
  175. Bustard, K. and Gupta, R. S. (1997) The sequences of heat shock protein 40 (DnaJ) homologs provide evidence for a close evolutionary relationship between the Deinococcus-thermus group and cyanobacteria. J. Mol. Evol. 45: 193-205.
  176. Schett, G., Metzler, B. Mayr, M., Xu, Q., Amberger, A., Neiderweiser, D., Gupta, R.S, Mizzen, L. and Wick, G. (1997) Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60. Atherosclerosis 128:27-38.
  177. Moudgil, K.D., Chang, T., Eradat, H., Chen, A.M., Gupta, R.S. Brahan, E. and Sercarz, E.E. (1997) Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis. J. Exp. Med. J. Exp. Med. 185: 1307-1316.
  178. Rey-Ladino, J., Joshi, P., Singh, B., Gupta, R.S. and Reiner, N.R. (1997) Leishmania major: molecular cloning, sequencing, and expression of the heat shock protein 60 gene reveals unique carboxy terminal peptide sequences. Exp. Parasitology 85: 249-263.
  179. Wax, M.B., Tefzel, G., Saito, I, Gupta, R.S., Harley, J.B., Zhengzhi, L. and Romano, C. (1998) Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma. Amer. Journal of Ophthalmology, 125: 145-157.
  180. Birnbaum, G., Kotilinek, L., Miller, S.D., Raine, C.S., Gao, Y.L., Lehmann, P.V. and Gupta, R.S. (1998) Heat shock proteins and experimental autoimmune encephalomyelitis. II: environmental infection and extra-neuraxial inflammation alter the course of chronic relapsing encephalomyelitis. J. Neuroimmunology 90: 149-161.
  181. Gupta, R.S. and Johari, V. (1998) Signature sequences in diverse proteins provide evidence of a close evolutionary relationship between the Deinococcus-Thermus group and cyanobacteria. J. Mol. Evol.46: 716-720.
  182. Gupta, R.S. (1998) What are archaebacteria: life’s third domain or monoderm prokaryotes related to gram-positive bacteria? A new proposal for the classification of prokaryotic organisms. Mol. Microbiol. 29: 695-708.
  183. Khan, I.U., Wallin, R., Gupta, R.S. and Kammer, G. L. (1998) Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane. Proc. Natl. Acad. Sci. USA. 95: 10425-10430.
  184. Gupta, R.S. (1998) Life’s third domain (Archaea): an established fact or an endangered paradigm? Theoret. Pop. Biol. 54: 91-104.
  185. Gupta, R.S. (1998) Protein phylogenies and signature sequences: A reappraisal of evolutionary relationships among archaebacteria, eubacteria, and eukaryotes. Microbiol. Mol. Biol. Rev. 62: 1435-1491.
  186. Gupta, R.S. (1999) Hsp70 sequences and the phylogeny of prokaryotes. Mol. Microbiol. 31: 1009-1010.
  187. Soltys, B.J. and Gupta, R S. (1999) Mitochondrial-matrix proteins at unexpected locations: are they exported? Trends in Biochem. Sci. 24, 174-177.
  188. Gupta, R. S., Mukhtar, T. and Singh, B. (1999) Evolutionary relationships among photosynthetic prokaryotes (Heliobacterium chlorum, Chloroflexus aurantiacus, cyanobacteria, Chlorobium tepidum and proteobacteria): implications regarding the origin of photosynthesis. Mol. Microbiol.32: 893-906.
  189. Soltys, B.J. and Gupta, R S. (1999) Mitochondrial-matrix proteins at unexpected cellular locations: export of proteins from mitochondria from an evolutionary perspective. Int. Rev. of Cytology. 194: 133-196.
  190. Gupta, R.S. (1999) Origin of eukaryotic cells: was metabolic symbiosis based on hydrogen the driving force? Trends in Biochem. Sci. 24: 423.
  191. Gupta, R.S. and Soltys, B.J. (1999) Lateral gene transfer, genome surveys and the Phylogeny of Prokaryotes (Comments). Science 286: 1443a.
  192. Tokunaga, H., Hara, S., Arkawa,T., Ishibashi, M., Gupta, R.S. and Tokunaga, M. (1999) Identification and partial purification of DnaK homologue from extremely halophilic archaebacteria, Halobacterium cutirubrum. J. Prot. Chem. 18:837-844.
  193. M. Maj, B. Singh and Gupta, R.S. (2000) The influence of inorganic phosphate on the activity of adenosine kinase. Biochem. Biophys. Acta. 1476: 33-42.
  194. Cechetto, J.D., Soltys, B.J. and Gupta, R S. (2000) Localization of mitochondrial 60-kD heat shock chaperonin (Hsp60) in pituitary growth hormone secretory granules and pancreatic zymogen granules. J. Histochem. Cytochem. 48: 45-56.
  195. Gupta, R.S. (2000) Evolutionary relationships among Bacteria: Does 16S rRNA provide all the answers? ASM News 66:189-190.
  196. Gupta, R.S.(2000) The natural evolutionary relationships among prokaryotes. Crit. Rev. Microbiol. 26: 111-131.
  197. Gupta, R.S. (2000) The phylogeny of proteobacteria: relationships to other eubacterial phyla and eukaryotes. FEMS Microbiol. Rev. 24: 367-402.
  198. Cechetto, J.D. and Gupta, R.S. (2000) Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites. Exp. Cell Res. 260: 30-39.
  199. Soltys, B.J., Kang, D. and Gupta, R.S. (2000) Localization of P32 protein (gC1q-R) in mitochondria and at specific extramitochondrial locations in normal tissues. Histochem. Cell Biol. 114: 245-255.
  200. Maj, M., Singh, B. and Gupta, R.S. (2000) Structure-activity studies on mammalian adenosine kinase. Biochem. Biophys. Res. Commun. 275: 383-393.
  201. Soltys, B.J., D.W. Andrews, Jemmerson,R. and Gupta, R.S. (2001) Cytochrome-C localizes in secretory granules in pancreas and anterior pituitary. Cell Biol. Internat. 25: 331-338.
  202. Singh, B., Lin, A., Wu, Z. C. and Gupta, R. S. (2001) Gene structure for adenosine kinase in Chinese hamster and human: high-frequency mutants of CHO cells involve deletions of several introns and exons. DNA and Cell Biol. 20: 53-65.
  203. Maj, M. and Gupta, R.S. (2001) The effect of inorganic phosphate on the activity of bacterial ribokinase. J. Prot. Chem 20: 139-144.
  204. Griffiths, E. and Gupta, R.S. (2001) The use of signature sequences in different proteins to determine the relative branching order of bacterial divisions: evidence that Fibrobacter diverged at a similar time to Chlamydia and the Cytophaga-Flavobacterium-Bacteroides division. Microbiology, 147: 2611-2622.
  205. Gupta, R. S. (2001) The branching order and phylogenetic placements of species from completed bacterial genomes based on conserved indels found in various proteins. International Microbiol. 4: 187-202.
  206. Sadacharan, S. K., Cavanagh, A.C. and Gupta, R. S. (2001) Immunoelectron microscopy provides evidence for the presence of mitochondrial heat shock 10-kDa protein (chaperonin 10) in red blood cells and a variety of secretory granules. Histochem. Cell Biol. 116: 507- 517.
  207. Hanlon, J.G., Adams, K., Rainbow, A.J., Gupta, R.S., Singh, G. (2001) Induction of Hsp60 by Photofrin-mediated photodynamic therapy. J Photochem Photobiol B. 64:55(1)61.
  208. Sigal, L. H., Williams, S., Soltys, B. and Gupta, R. S. (2001) H9724, a monoclonal antibody to Borrelia burgdorferi’s flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme disease. Cell. Mol. Neurobiol. 21:477-495.
  209. Maj, M.C., Singh, B. and Gupta, R. S. (2002) Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: identification of a novel motif implicated in phosphate and magnesium ion binding and substrate inhibition. Biochemistry, 41: 4059-69.
  210. Cechetto, J.D., Sadacharan, S.K., Berk, P.D. and Gupta, R. S. (2002) Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues. Histol. Histopathol. 17, 353-364.
  211. Griffiths, E. and Gupta, R. S. (2002) Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA between chlamydiae and Streptomyces. Microbiology 148: 2541-2549.
  212. Gupta, R. S. and Griffiths, E. (2002) Critical Issues in bacterial phylogeny. Theoret. Pop. Biol. 61: 423-434.
  213. Gupta, R. S. (2002) Phylogeny of Bacteria: Are we now close to understanding it? ASM News, 284: 284-291.
  214. Gupta, R. S. (2003) Evolutionary relationships among photosynthetic bacteria (PDF). Photosynth. Res. 76: 173-183.
  215. Gupta, R. S., Pereira, M., Chandrasekera, C. and Johari, V. (2003) Molecular signatures in protein sequences that are characteristic of cyanobacteria and plastid homologues. Int. J. Syst. Evol. Microbiol. 53: 1833-1842.
  216. Park, J., Singh, B., Maj, M. and Gupta, R. S. (2004) Phosphorylated derivatives that activate or inhibit mammalian adenosine kinase provide insights into the role of pentavalent ions in AK catalysis. J. Protein Chemistry 23: 167-177.
  217. Singh, B. and Gupta, R. S. (2004) Genomic organization and linkage via a bidirectional promoter of the AP-3 (adaptor protein-3) mu3A and AK (adenosine kinase) genes: deletion mutants of AK in Chinese hamster cells extend into the AP-3 mu3A gene. Biochemical Journal 378: 519-528.
  218. Durai, M., Gupta, R. S. and Moudgil, K.D. (2004) The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis. J. Immunol. 172: 2795-2802.
  219. Griffiths, E. and Gupta, R. S. (2004) Signature sequences in diverse proteins provide evidence for the late divergence of the Order Aquificales. International Microbiol. 7: 41-52.
  220. Gupta, R.S. (2004) The phylogeny and signature sequences characteristics of Fibrobacteres, Chlorobi, and Bacteroidetes. Crit. Rev. in Microbiology 30: 123-143.
  221. Griffiths, E. and Gupta, R.S. (2004) Distinctive protein signatures provide molecular markers and evidence for the monophyletic nature of the deinococcus-thermus phylum. J. Bacteriol. 186: 3097-3107.
  222. Bowes, T.J. and Gupta, R.S. (2005) Induction of mitochondrial fusion by cysteine-alkylators ethacrynic acid and N-ethylmaleimide. J. Cell. Physiol. 202: 796-804.
  223. Griffiths, E., Petrich, A., & Gupta, R. S. (2005) Conserved indels in essential proteins that are distinctive characteristics of Chlamydiales and provide novel means for their identification. Microbiology, 151: 2647-2657.
  224. Gupta, R. S. (2005) Protein signatures distinctive of alpha proteobacteria and its subgroups and a model for alpha-proteobacterial evolution. Crit. Rev. Microbiol. 31: 101-135.
  225. Kainth, P. & Gupta,R.S. (2005). Signature proteins that are distinctive of alpha proteobacteria. BMC Genomics, 6: 94.
  227. Gao, B. and Gupta, R. S. (2005) Conserved indels in protein sequences that are characteristics of the phylum Actinobacteria. Int. J. Syst. Evol. Microbiol. 55: 2401-2412.
  228. Gupta, R. S. and Griffiths, E. (2006) Chlamydiae-specific proteins and indels: novel tools for studies. Trends in Microbiology. 14: 527-535.
  229. Gupta, R. S and Sneath, P.H.A. (2006) Application of the character compatibility approach to generalized molecular sequence data: branching order of the proteobacterial subdivisions. J. Mol. Evol. 64: 90-100.
  230. Ventura, M., Canchaya, C., Fitzgerald, G. F., Gupta, R. S. and van Sinderen, D. (2006) Genomics as a means to understand bacterial phylogeny and ecological adaptation: the case of bifidobacteria. Antonie van Leeuwenhoek. Oct 26 (Epub).
  231. Gupta, R. S. (2006) Molecular signatures (unique proteins and conserved indels) that are specific for the epsilon proteobacteria (Campylobacterales). BMC Genomics. 2006 Jul 4;7(1):167.
  232. Griffiths, E. and Gupta, R. S. (2006) Lateral transfers of serine hydroxymethyltransferase (glyA) and UDP-N-acetylglucosamine enolpyruvyl transferase (murA) genes from free-living Actinobacteria to the parasitic chlamydiae. J. Mol. Evol. 63: 283-296.
  233. Griffiths, E., Ventresca, M. S. & Gupta, R. S. (2006) BLAST screening of chlamydial genomes to identify signature proteins that are unique for the Chlamydiales, Chlamydiaceae, Chlamydophila and Chlamydia groups of species. BMC Genomics 7: 14.
  234. Gao, B., Paramanathan, R. and Gupta, R. S. (2006) Signature proteins that are distinctive characteristics of Actinobacteria and their subgroups. Antonie van Leeuwenhoek, 90: 69-91.
  235. Griffiths, E. and Gupta, R. S. (2006) Molecular Signatures in protein sequences that are characteristics of the phylum Aquificae. Int. J. Syst. Evol. Microbiol. 56: 99-107.
  236. Bowes, T., Singh, B. and Gupta, R. S. (2006) Subcellular localization of fumarase in mammalian cells and tissues. Histochem. Cell Biology. Nov 17 (Epub).
  238. Park, J., Vaidyanathan, G., Singh, B. and Gupta, R.S. (2006) Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase. The Protein Journal. (in press).
  239. Park, J., Singh, B. and Gupta, R. S. (2006) Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives. Mol. Cell. Biochem. 283: 11-21.
  240. Gupta, R. S. and Sneath, P. H. (2007) Application of the character compatibility approach to generalized molecular sequence data: branching order of the proteobacterial subdivisions. J Mol Evol. 64(1): 90-100.
  241. Gao, B. and Gupta, R. S. (2007) Phylogenomic analysis of proteins that are distinctive of Archaea and its main subgroups and the origin of methanogenesis. BMC Genomics. 8: 86.
  242. Gupta, R. S. and Lorenzini, E. (2007) Phylogeny and molecular signatures (conserved proteins and indels) that are specific for the Bacteroidetes and Chlorobi species. BMC Evol Biol. 7: 71.
  243. Park, J., van Koeverden, P., Singh, B. and Gupta, R. S. (2007) Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase. FEBS Lett. 581(17): 3211-6.
  244. Gupta, R. S. and Mok, A. (2007) Phylogenomics and signature proteins for the alpha proteobacteria and its main groups. BMC Microbiol. 7: 106.
  245. Griffiths, E. and Gupta, R. S. (2007) Identification of signature proteins that are distinctive of the Deinococcus-Thermus phylum. Int Microbiol. 10(3): 201-8.
  246. Park, J. and Gupta, R. S. (2008) Adenosine kinase and ribokinase–the RK family of proteins. Cell Mol Life Sci. 65(18): 2875-96.
  247. Gupta, R. S., Ramachandra, N. B., Bowes, T. and Singh, B. (2008) Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10. Novartis Found Symp. 291: 59-68.
  248. Bowes, T. and Gupta, R. S. (2008) Novel mitochondrial extensions provide evidence for a link between microtubule-directed movement and mitochondrial fission. Biochem Biophys Res Commun. 376(1): 40-5.
  249. Singh, B. and Gupta, R. S. (2009) Conserved inserts in the Hsp60 (GroEL) and Hsp70 (DnaK) proteins are essential for cellular growth. Mol Genet Genomics. 281(4): 361-73.
  250. Gao, B., Mohan, R. and Gupta, R. S. (2009) Phylogenomics and protein signatures elucidating the evolutionary relationships among the Gammaproteobacteria. Int J Syst Evol Microbiol. 59(Pt 2): 234-47.
  251. Gupta, R. S. and Gao B. (2009) Phylogenomic analyses of clostridia and identification of novel protein signatures that are specific to the genus Clostridium sensu stricto (cluster I). Int J Syst Evol Microbiol. 59(Pt 2): 285-94.
  252. Park, J., Singh, B. and Gupta, R. S. (2009) Mycobacterial adenosine kinase is not a typical adenosine kinase. FEBS Lett. 583(13):2231-6.
  253. Gao, B., Sugiman-Marangos, S., Junop, M. S. and Gupta, R. S. (2009) Structural and phylogenetic analysis of a conserved actinobacteria-specific protein (ASP1; SCO1997) from Streptomyces coelicolor. BMC Struct Biol. 9: 40.
  254. Gupta, R. S. (2009) Protein signatures (molecular synapomorphies) that are distinctive characteristics of the major cyanobacterial clades. Int J Syst Evol Microbiol. 59(Pt 10): 2510-26.
  255. Cui, X. A., Singh, B., Park, J. and Gupta, R. S. (2009) Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus. Biochem Biophys Res Commun. 388(1): 46-50.
  256. Gupta, R. S. and Mathews, D. W. (2010) Signature proteins for the major clades of Cyanobacteria. BMC Evol Biol. 10: 24.
  257. Lorenzini, E., Singer, A., Singh, B., Lam, R., Skarina, T., Chirgadze, N. Y., Savchenko, A. and Gupta, R. S. (2010) Structure and protein-protein interaction studies on Chlamydia trachomatis protein CT670 (YscO Homolog). J Bacteriol. 192(11): 2746-56.
  258. Gupta, R. S. (2010) Molecular signatures for the main phyla of photosynthetic bacteria and their subgroups. Photosynth Res. 104(2-3): 357-72.
  259. Gupta, R. S. and Shami, A. (2011) Molecular signatures for the Crenarchaeota and the Thaumarchaeota. Antonie Van Leeuwenhoek. 99(2): 133-57.
  260. Gupta, R. S. and Bhandari, V. (2011) Phylogeny and molecular signatures for the phylum Thermotogae and its subgroups. Antonie Van Leeuwenhoek. 100(1): 1-34.
  261. Cui, X. A., Agarwal, T., Singh, B. and Gupta, R. S. (2011) Molecular characterization of chinese hamster cells mutants affected in adenosine kinase and showing novel genetic and biochemical characteristics. BMC Biochem. 12(1): 22.
  262. Gupta, R. S. (2011) Origin of diderm (Gram-negative) bacteria: antibiotic selection pressure rather than endosymbiosis likely led to the evolution of bacterial cells with two membranes. Antonie Van Leeuwenhoek. 100(2): 171-82.
  263. Naushad, H.S. and Gupta, R.S. (2011) Molecular signatures (conserved indels) in protein sequences that are specific for the order Pasteurellales and distinguish two of its main clades. Antonie Van Leeuwenhoek. Aug 10, (Epub ahead of print).
  264. Ahmod, N.Z., Gupta, R.S. and Shah, H.N. (2011) Identification of a Bacillus anthracis specific indel in the yeaC gene and development of a rapid pyrosequencing assay for distinguishing B. anthracis from the B. cereus group. J. Microbiol. Methods Sept 2, (Epub ahead of print).
  265. Gao, B. and Gupta, R.S. (2011) Molecular Systematics in the Post-genomic Era. Invited Perspective: Antonie Van Leeuwenhoek. (In press).
  1. Gupta, R.S. (Member of Panel) (1973). Bal-Vaigyanik (A workbook in Science for school children in Hindi), Thompson Press, Faridabad, India.
  2. Gupta, R.S. and Goldstein, S. (1981). Mutagen testing in the human fibroblast diphtheria toxin resistance (HF DipR) system. In Progress in Mutation Research, Vol. 1 “Evaluation of Short Term Tests for Carcinogens” (J.F. de Serres and J. Ashby, eds.) Elsevier/North-Holland, p. 614-625.
  3. Brookes, P. et al., (1981). Summary Report on the Performance of In Vitro Mammalian Assays. In Progress in Mutation Research, Vol. 1. “Evaluation of Short-Term Tests for Carcinogens” (J.F. de Serres and J. Ashby, eds.), Elsevier/North-Holland, pp. 77-85.
  4. Gupta, R.S. (1983). Emetine, cryptopleurine, tylocrebrine and other functionally related alkaloids. In Antibiotics, Vol. VI. (F.E. Hahn and J.W. Corcoran, eds.), Springer-Verlag, Germany, p. 46-70.
  5. Gupta, R.S. (1984). Genetic markers for quantitative mutagenesis studies in CHO cells: Applications to mutagen screening studies. “Handbook of Mutagenicity Test Procedures.” Second edition (B.J. Kilbey et al. eds.), Elsevier Scientific Co., New York, pp. 291-319.
  6. Gupta, R.S. (1985) Mutations and the cross-resistance pattern among anticancer drugs, In “Medical Research in Canada” (J. Gerrard, ed.), White Horse Plains Publ., Manitoba, 87-91.
  7. Gupta, R.S. and Mehta, K.D. (1986). Genetic and biochemical characteristics of three different types of mutants of mammalian cells affected in adenosine kinase. In Purine Metabolism in Man V. (W.L. Nyhan, ed.)., Plenum Press, 595-604.
  8. Gupta, R.S. (Editor) (1989) Drug Resistance in Mammalian Cells, Vol. 1. Antimetabolites, CRC Press, Florida ISBN 0-8493-6921-5.
  9. Gupta, R.S. (Editor) (1989) Drug Resistance in Mammalian Cells, Vol. 2, Anticancer and Other Drugs, CRC Press, Florida ISBN 0-8493-6922-3.
  10. Gupta, R.S. (1989) Purine nucleoside analogs. In “Drug Resistance in Mammalian Cells” Vol. I, Gupta, R.S. (ed.) CRC Press, pp. 89-110.
  11. Gupta, R.S. and Ross, W.E. (1989) Etoposide(VP-16), teniposide and related epipodophyllotoxin derivatives. In “Drug Resistance in Mammalian Cells”, Vol. II, Gupta, R.S. (ed.) CRC Press, pp. 89-108.
  12. Gupta, R.S. (1989) Antimitotic drugs (Podophyllotoxin, Nocodazole, Taxol, Griseofulvin and others) In “Drug Resistance in Mammalian Cells”, Vol. II, Gupta, R.S. (ed.) CRC Press, pp. 109-138.
  13. Gupta, R.S. (1989) Emetine, Cryptopleurine, Tylocrebrine and related protein synthesis inhibitors. In “Drug Resistance in Mammalian Cells”, Vol. II, Gupta, R.S. (ed.) CRC Press, pp. 175-186.
  14. Gupta, R.S. (1989) Diphtheria Toxin. In “Drug Resistance in Mammalian Cells”, Vol. II, Gupta, R.S. (ed.) CRC Press, pp. 187-200.
  15. Gupta, R.S. and Chopra, A. (1989) Cardiac Glycosides and related Steroids. In “Drug Resistance in Mammalian Cells”, Vol. II, Gupta, R.S. (ed.) CRC Press, pp. 215-234.
  16. Gupta R.S., Dudani, A.K. and Jindal, S. (1989) Miscellaneous Agents II. In “Drug Resistance in Mammalian Cells”, Vol. II, Gupta, R.S. (ed.) CRC Press, pp. 269-286.
  17. Gupta, R.S. (1989) 5,6-Dichloro Ribofuranosyl benzimidazole (DRB). In “Drug Resistance in Mammalian Cells”, Vol. II Gupta, R.S. (ed.) CRC Press, pp. 167-174.
  18. Dudani, A.K., Jindal, S. and Gupta, R.S. (1989) Miscellaneous Agents I. In “Drug Resistance in Mammalian Cells”, Vol. I, Gupta, R.S. (ed.) CRC Press, pp. 246-258.
  19. Gupta, R.S. (1996) The Chaperonins: Evolutionary relationships. In “The Chaperonins”. (R.J. Ellis, editor), Academic Press, NY, pp. 27-64.
  20. Gupta, R.S. (1996) Protein phylogenies and the evolutionary relationships between prokaryotes and eukaryotes. In: Culture Collection to Improve the Quality of Life (R.A. Samson, J.A. Staplers, D. Vandermei and A.H. Stouthamer, eds.) Ponsen & Looyen, The Netherlands, pp. 83-90.
  21. Soltys, B.J. and Gupta, R.S. (1998) Mitochondrial molecular chaperones hsp60 and mhsp70: Are their roles restricted to mitochondria? In Stress Proteins, Handbook of Experimental Pharmacology (D.S. Latchman ed.)vol. 136: 69-100.
  22. Gupta, R. S. (1999) Protein phylogenies and a new proposal for the classification of organisms unifying cell structure and molecular sequence data. In Endocytobiology VII, E. Wagner et al. (Eds.), University of Geneva; 271-289.
  23. Gupta, R. S. (2004) The Outlines of Bacterial Evolution. In “Origins: Genesis, Evolution and Diversity of Life” J. Seckbach (Ed.) Kluwer Academic Publishers. 263-279.
  24. Gupta, R. S. (2005) Molecular Sequences and the Early History of Life. In “Microbial Phylogeny and Evolution” J. Sapp (Ed.) Oxford University Press. 160-183.
  25. Gupta, R.S., Bowes, T., Sadacharan, S. and Singh, B. (2005) Disposition of mitochondrial molecular Chaperones (Hsp60, mHsp70, Cpn10 and TRAP-1). In “Extracellular Biology of Molecular Chaperones” B. Henderson and A.G. Pockley (Eds.), Cambridge University Press (in press).
  26. Gupta, R.S. and Gao, B. (2010) Recent advances in understanding microbial systematics, In “Microbial Population Genetics” Jianping Xu (Ed), Caister Academic Press.
  27. Gupta, R.S. (2010) Microbial phylogeny and evolution based on protein sequences. In “Mass Spectrometry for Microbial Proteomics, Haroun N. Shah and Saheer E. Gharbia (Eds.) Wiley-Blackwell Publishers, Oxford, England.
  28. Gupta, R.S. (2010) Applications of conserved indels for understanding microbial phylogeny. In “Molecular Phylogeny of Microorganisms” A. Oren and R. T. Thapke (Eds.) Academic Press.